Supporting information- Oxa, Thia, Heterocycle and Carborane Analogs of SQ109: Bacterial and Protozoal Cell Growth Inhibitors

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Title: Supporting information- Oxa, Thia, Heterocycle and Carborane Analogs of SQ109: Bacterial and Protozoal Cell Growth Inhibitors
Authors: Kai Li, Yang Wang, Gyongseon Yang, Sooyoung Byun, Guodong Rao, Carolyn Shoen, Hongliang Yang, Anmol Gulati, Dean C. Crick, Michael Cynamon, Guozhong Huang, Roberto Docampo, Joo Hwan No, and Eric Oldfield
Date: 2015/04/17
Reference: ACS, Infectious Diseases, April 10, 2015, Volume 1, Issue 4, Pages 149-184
Download link:  http://mestrelab.com/pdf/publications/acsinfecdis-supporting-information.pdf

 

This supporting document published by Eric Oldfield shows that all final compounds were ≥90% pure as determined by quantitative spin count NMR (qNMR, processed with Mnova NMR software).

Full details of all assays; representative dose −response curves; selectivity index results; mitochondrial membrane bioenergetics; full synthesis and characterization of SQ-109 and its analogues as well as qNMR spectra are shown on this supporting information (PDF)

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