Mestrelab Research S.L. and AFFINImeter reach an agreement


Mestrelab Research and Software 4 Science Developments-AFFINImeter have agreed to boost the use of advanced analysis of binding isotherms from 2D-NMR titrations. For this reason, all users interested in purchasing a license for Mnova Binding will benefit from a free annual license of AFFINImeter for Nuclear Magnetic Resonance package.

Mnova Binding is a powerful tool that automatically processes 2D HSQC type of protein-ligand titration spectra, tracks the peak movement and computes the Kd‘s for multiple peaks.

  • Intuitive workflow that allows you to analyze CSP titration spectra interactively or fully automatically.
  •  Automatic peak movement tracking and measurement of chemical shift perturbations (CSPs), fitting them to the concentrations of ligands to compute Kd.
  •  Corrects the automatic peak movement tracking in crowded spectral areas.
  •  Provides tools for processing and stacking multiple 2D HSQC spectra. It displays them in different colors.
  •  Easy exporting of CSP values for further studies of the ligand-protein binding models.

AFFINImeter for Nuclear Magnetic Resonance allows the advanced analysis of binding isotherms from 2D NMR titrations to measure binding constants (KA). The binding isotherms are imported directly from the software Mnova and a series of advanced tools are available in AFFINImeter-NMR to get the most out of your NMR data including:

  • Global analysis of binding isotherms.
  • Analysis with complex binding models
  • Advanced algorithms to guarantee convergence avoiding local minima, as well as to assess the parameter uncertainties, the goodness of fit and result reliability.
Instructions to start (PDF)

More info here: Start using AFFINImeter-NMR


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