Enabling fast Pseudo-2D NMR Acquisition for Broadband Homonuclear Decoupling – The EXACT NMR approach

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Title: Enabling fast Pseudo-2D NMR Acquisition for Broadband Homonuclear Decoupling – The EXACT NMR approach
Authors: Ikenna Ndukwe, Alexandra Shchukina, Vadim Zorin, Carlos Cobas, Krzysztof Kazimierczuk,
Craig Butts
Date: 30 May 2017
Reference:

ChemPhysChem – 

DOI: 10.1002/cphc.201700474
Download link: http://onlinelibrary.wiley.com/doi/10.1002/cphc.201700474/full

 

ABSTRACT

Pseudo-2D NMR provides a means of acquiring broadband homonuclear decoupled spectra useful for structural characterization of complex molecules. However, data points concatenated in the direct dimension in these experiments are acquired over incremented time periods – leading to long acquisition times with no sensitivity benefits due to the absence of signals averaging between scans. Herein, the concept of EXACT NMR (‘burst’ non-uniform sampling of data points) is explored in pseudo-2D experiments with results revealing little or no loss in spectral quality or signal intensity despite the acceleration of acquisition – up to 400% in some cases.

 

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Enrique Sánchez

Scientific Content Editor in Mestrelab Research S.L. Read his profile here.

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